Analisis Senyawa Kurkumin Pada Tanaman Kunyit (Curcuma Longa) Sebagai Obat Herbal Gastritis Menggunakan Analisis Pass, Swiss Adme Dan Docking
Abstract
Curcuma longa atau dikenal dengan kunyit merupakan tanaman obat herbal yang sering digunakan dalam pengobatan tradisional. digunakan dalam pengobatan baik secara tradisional maupun medis karena mempunyai banyak senyawa aktif salah satunya adalah kurkumin. senyawa aktif salah satunya adalah kurkumin. Gastritis merupakan salah satu penyakit yang sering dikeluhkan masyarakat. Gastritis disebabkan oleh naiknya asam lambung sehingga menyebabkan peradangan pada mukosa lambung. Sekresi asam lambung diatur oleh protein protein histamin H2. Penelitian ini bertujuan untuk mengetahui potensi senyawa kurkumin dalam menghambat histamin H2 pada sekresi asam lambung. menghambat histamin H2 pada sekresi asam lambung menggunakan metode uji senyawa obat Lipinski rule dengan Swiss ADME, PASS test, dan molekuler docking. Berdasarkan hasil docking menunjukkan bahwa senyawa kurkumin dengan reseptor histamin H2 menghasilkan nilai afinitas pengikatan sebesar - 6,6. Reseptor ini menghasilkan nilai afinitas pengikatan sebesar -6,9 kkal/mol yang berarti kurkumin dapat digunakan sebagai kandidat obat maag. digunakan sebagai calon obat maag.
References
Adiatma, D., Diah Utami, P., Pranitasari, N., & Rasyida, A. U. (2023). Inhibisi Senyawa Aktif Ekstrak Sirsak (Annona Muricata) Terhadap Pertumbuhan Plasmodium falciparum Berdasarkan Studi In Silico Inhibition of Active Compounds Soursop (Annona Muricata) Extract On Plasmodium falciparum’ Growth using In Silico Study. 12, 323–333. https://journal.unesa.ac.id/index.php/lenterabio/index323
Arwansyah, Ambarsari, L., & Sumaryada, T. I. (2014). Simulasi Docking Senyawa Kurkumin Dan Analognya Sebagai Inhibitor Enzim 12-Lipoksigenase. Current Biochemistry, 1(1), 11–19.
Arwansyah, & Hasrianti. (2014). Simulasi Molecular Docking Senyawa Kurkumin dan Analognya Sebagai Selective Androgen Receptor Modulators (SARMs) Pada Kanker Prostat. Jurnal Dinamika, 5(2), 60–75.
Conrad, M., Söldner, C. A., Miao, Y., & Sticht, H. (2020). Agonist binding and g protein coupling in histamine h2 receptor: A molecular dynamics study. International Journal of Molecular Sciences, 21(18), 1–18. https://doi.org/10.3390/ijms21186693
Daina, A., Michielin, O., & Zoete, V. (2017). SwissADME: A free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Scientific Reports, 7(January), 1–13. https://doi.org/10.1038/srep42717
Fakih, T. M., Jannati, F. A., Meilani, A., Ramadhan, D. S. F., & Darusman, F. (2022). Studi In Silico Aktivitas Analog Senyawa Zizyphine dari Bidara Arab (Zizyphus spina-christi) sebagai Antivirus SARS-CoV-2 terhadap Reseptor 3CLpro. ALCHEMY Jurnal Penelitian Kimia, 18(1), 70. https://doi.org/10.20961/alchemy.18.1.52188.70-79
Gerungan, Y. Y., Kepel, B. J., Fatimawali, ., Manampiring, A., Budiarso, F. D., & Bodhi, W. (2021). Molekuler Docking tehadap Senyawa Eugenol dan Myricetin pada Tanaman Cengkeh (Syzygium aromaticum) sebagai Penghambat Pertumbuhan SARS-CoV-2. Jurnal E-Biomedik, 9(1), 21–25. https://doi.org/10.35790/ebm.v9i1.31748
Isyaku, Y., Uzairu, A., & Uba, S. (2020). Computational studies of a series of 2-substituted phenyl-2-oxo-, 2-hydroxyl- and 2-acylloxyethylsulfonamides as potent anti-fungal agents. Heliyon, 6(4), e03724. https://doi.org/10.1016/j.heliyon.2020.e03724
Kalita, J., Chetia, D., & Rudrapal, M. (2019). Molecular Docking, Drug-Likeness Studies and ADMET Prediction of Quinoline Imines for Antimalarial Activity. Chemical Science Transactions, 8(2), 208–218. https://doi.org/10.7598/cst2019.1569
Lestari, D., Putri, R., & Sari, A. (2023). Efektivitas Pemberian Salep Kunyit Terhadap Striae Gravidarum Pada Ibu Hamil Trimester Ii Di Pandeglang. SENTRI: Jurnal Riset Ilmiah, 2(11), 4968–4978. https://doi.org/10.55681/sentri.v2i11.1845
Mauliana, L., Jamil, A. S., & Siti, S. (2022). Curcuma longa as a Natural Immunomodulator for Preventing infection from COVID 19 With an In Silico Approach. Jurnal Biologi Tropis, 22(2), 345–352. https://doi.org/10.29303/jbt.v22i2.3281
Mustakim, Rimbawati, Y., & Wulandari, R. (2021). Edukasi Pencegahan Dan Penanganan Gastritis Pada Siswa Bintara Polda Sumatera Selatan. Pengabdian Kepada Masyarakat, 3(2), 1–4.
Naito, Y., Takagi, T., & Yoshikawa, T. (2010). Lansoprazole, a proton pump inhibitor, to reduce gastrointestinal inflammation via heme oxygenase-1 induction. Molecular and Cellular Pharmacology, 2(2), 53–60. https://doi.org/10.4255/mcpharmacol.10.08
Naufa, F., Mutiah, R., Yen, Y., & Indrawijaya, A. (2022). Studi in Silico Potensi Senyawa Katekin Teh Hijau (Camellia sinensis) sebagai Antivirus SARS CoV-2 terhadap Spike Glycoprotein (6LZG) dan Main Protease (5R7Y). J.Food Pharm.Sci, 2022(1), 584–596. www.journal.ugm.ac.id/v3/JFPA
Nisfiyanti, Y. (2012). Traditional Medicine (A Case Study in The Village of Juntinyuat, District of Juntinyuat, Regency of Indramayu). Patanjala, 4(1), 129–140.
Rachmadani, A. (2020). CASE REPORT Oceana Biomedicina Journal Vol 3 No 2 Jul – Dec 2020. 3(2), 21–37.
Rena, S. R., Nurhidayah, N., & Rustan, R. (2022). Analisis Molecular Docking Senyawa Garcinia Mangostana L Sebagai Kandidat Anti SARS-CoV-2. Jurnal Fisika Unand, 11(1), 82–88. https://doi.org/10.25077/jfu.11.1.82-88.2022
Sari, I. W., Junaidin, J., & Pratiwi, D. (2020). STUDI MOLECULAR DOCKING SENYAWA FLAVONOID HERBA KUMIS KUCING (Orthosiphon stamineus B.) PADA RESEPTOR α-GLUKOSIDASE SEBAGAI ANTIDIABETES TIPE 2. Jurnal Farmagazine, 7(2), 54. https://doi.org/10.47653/farm.v7i2.194
Sultan, M. A., Galil, M. S. A., Al-Qubati, M., Omar, M. M., & Barakat, A. (2020). Synthesis, molecular docking, druglikeness analysis, and admet prediction of the chlorinated ethanoanthracene derivatives as possible antidepressant agents. Applied Sciences (Switzerland), 10(21), 1–23. https://doi.org/10.3390/app10217727
Suwindiri, Yulius Tiranda, W. A. C. N. (2021). FAKTOR PENYEBAB KEJADIAN GASTRITIS DI INDONESIA : LITERATURE REVIEW Mahasiswa IKesT Muhammadiyah Palembang , Sumatera Selatan , Indonesia IKesT Muhammadiyah Palembang , Sumatera Selatan , Indonesia. Jurnal Keperawatan Merdeka (JKM), 1(November), 209–223.
Waring, M. J. (2010). Lipophilicity in drug discovery. Expert Opinion on Drug Discovery, 5(3), 235–248. https://doi.org/10.1517/17460441003605098.
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